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The validity and responsiveness of the EQ-5D measure of health-related quality of life in an adolescent population with persistent major depression
- Author:
- BYFORD Sarah
- Journal article citation:
- Journal of Mental Health, 22(2), 2013, pp.101-110.
- Publisher:
- Taylor and Francis
- Place of publication:
- London
Background: Despite a preference for economic evaluations to measure outcomes in terms of quality-adjusted life years, generic measures of outcome are rarely used in mental health research involving young people. Aims: To explore the validity and responsiveness of the EQ-5D measure of health-related quality of life in adolescents with major depression. Method: Data came from a clinical trial involving adolescents with persistent major depression (n = 199). Construct validity was tested using socio-demographic constructs and baseline clinical outcome scores. To assess convergent validity, correlation between EQ-5D and clinical outcome scores was tested. To assess responsiveness, the mean change in EQ-5D scores of participants categorised as improved versus not improved on clinical outcome measures was tested. Results: Significant differences in mean EQ-5D score were found for co-morbidity and three of four severity measures but not gender, age, treatment history or suicide attempts. Mean EQ-5D scores were significantly correlated with all clinical outcome measures, although relationships were moderate or weak. A change in mean EQ-5D score was significantly related to clinical assessments of improvement on all outcome measures. Conclusions: Results provide initial evidence to support the relevance of the EQ-5D in adolescents with major depression, but this evidence is weak. Replication studies are needed to assess the generalisability of these findings. (Publisher abstract)
Economic evaluations of child and adolescent mental health interventions: a systematic review
- Authors:
- ROMEO Renee, BYFORD Sarah, KNAPP Martin
- Journal article citation:
- Journal of Child Psychology and Psychiatry, 46(9), 2005, pp.919-930.
- Publisher:
- Wiley
It is increasingly recognised that economic information on the impacts of child and adolescent mental health problems, and the cost-effectiveness of interventions is needed. This review identifies 14 full economic evaluations (covering both costs and clinical outcomes) and seven cost-offset studies (examining only costs) of a variety of mental health problems and intervention approaches. Behavioural disorders have been given relatively greater attention in economic evaluations, and tentatively suggest child behavioural gains and parent satisfaction from parent and child training programmes. However, the cost-effectiveness of the location of delivery for behavioural therapies is less clear. In general, the quality of evaluations was limited by small sample sizes, constrained measurement of costs, narrow perspectives and over-simple statistical and econometric methods.