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Clozapine use in women with borderline personality disorder and co-morbid learning disability
- Authors:
- FAJUMI Tolulope, MANZOOR Maryam, CARPENTER Katie
- Journal article citation:
- Journal of Learning Disabilities and Offending Behaviour, 3(1), 2012, pp.6-11.
- Publisher:
- Emerald
This study tested the hypothesis that Clozapine reduces the rates of self-injury and the use of restraint in a medium secure setting in female patients who have a diagnosis of borderline personality disorder (BPD) and mild learning disability. Data were gathered for patients with six months baseline data on rates of self-injury and the use of restraint, and six months on Clozapine. The mean number of incidents of self-injury in the six months prior to Clozapine was 20.75, and 13.5 in the six months following Clozapine, a reduction of 35%. The mean number of incidents of restraint in the six months prior to Clozapine was 17.75 compared with 9.25 in the six months following commencement of Clozapine, a reduction of 4%. This study demonstrates a reduction in the rates of self-injury and use of restraint in women with a diagnosis of BPD when treated with Clozapine which was clinically significant although not statistically significant.