Search results for ‘Subject term:"dual diagnosis"’ Sort:
Results 1 - 2 of 2
Genotype effects of CHRNA7, CNR1 and COMT in schizophrenia: interactions with tobacco and cannabis use
- Authors:
- ZAMMIT Stanley, et al
- Journal article citation:
- British Journal of Psychiatry, 191(11), November 2007, pp.402-407.
- Publisher:
- Cambridge University Press
Genetic variations might modify associations between schizophrenia and cannabis or tobacco use. The aim was to examine whether variants within the cannabinoid receptor (CNR1) and 7 nicotinic receptor (CHRNA7) genes are associated with schizophrenia, and whether these effects vary according to cannabis or tobacco use. The study also examined a putative interaction between cannabis and Val158Met within the catechol-O-methyltransferase gene (COMT). Genotype effects of CHRNA7 and CNR1 were studied in a case–control sample of 750 individuals with schizophrenia and 688 controls, with interactions for these genes studied in small subsamples. A case-only design of 493 of the schizophrenia group was used to examine interactions between cannabis use and COMT. There was no evidence of association between schizophrenia and CNR1 or CHRNA7 genotypes, or of interactions between tobacco use and CHRNA7, or cannabis use and CNR1 or COMT genotypes. Neither CNR1 nor CHRNA7 variation appears to alter the risk of schizophrenia. Furthermore, the results do not support the presence of different effects of cannabis use on schizophrenia according to variation within COMT.
Self reported cannabis use as a risk factor for schizophrenia in Swedish conscripts of 1969: historical cohort study
- Authors:
- ZAMMIT Stanley, et al
- Journal article citation:
- British Medical Journal, 23.11.02, 2002, pp.1199-1201.
- Publisher:
- British Medical Association
An association between use of cannabis in adolescence and subsequent risk of schizophrenia was previously reported in a follow up of Swedish conscripts. Arguments were raised that this association may be due to use of drugs other than cannabis and that personality traits may have confounded results. Cannabis use is associated with an increased risk of developing schizophrenia, consistent with a causal relation. This association is not explained by use of other psychoactive drugs or personality traits relating to social integration.