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Fluoxetine in adolescents with comorbid major depression and an alcohol use disorder a five-year follow-up study
- Authors:
- CORNELIUS Jack R., et al
- Journal article citation:
- Journal of Dual Diagnosis, 2(1), 2005, pp.11-25.
- Publisher:
- Taylor and Francis
- Place of publication:
- Philadelphia, USA
The goal of this five-year follow-up evaluation was to characterize the long-term (five-year) clinical course following the completion of an acute phase study with fluoxetine in comorbid adolescents. At the five-year follow-up evaluation, the group continued to demonstrate significantly fewer criteria for an Alcohol Use Disorder (AUD) and fewer depressive symptoms, and also consumed fewer standard drinks than they had demonstrated at the baseline of the acute phase study. Also, between the three and five-year follow-up assessments, the level of self-reported depressive symptoms showed a significant decrease. Despite their substantial residual depression and alcohol use, a strong majority (8/10, 80%) of the subjects graduated from college during the five-year follow-up period. It is concluded that the long-term (5-year) prognosis for the AUD, CD, and academic functioning of comorbid adolescents following acute phase treatment with SSRIs is surprisingly good. However, the long-term prognosis for their depression was surprisingly poor, and was worse than is typically seen among non-comorbid adolescents or adults. (Copies of this article are available from: Haworth Document Delivery Centre, Haworth Press Inc., 10 Alice Street, Binghamton, NY 13904-1580).