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Depressive symptoms among cognitively normal versus cognitively impaired elderly subjects
- Authors:
- LI Yang-Sheng, MEYER John S., THORNBY John
- Journal article citation:
- International Journal of Geriatric Psychiatry, 16(5), May 2001, pp.455-461.
- Publisher:
- Wiley
Article analyses the prevalence and severity of depressive symptoms among patients with Alzheimer's disease (DAT), vascular dementia (VAD), and among the cognitively normal elderly. Risk factors contributing to depression were likewise evaluated. Found that prevalence of depressive symptoms among VAD, DAT, and cognitively normal elderly were 31.4%, 19.9%, and 13.2%, respectively. 25.5% of VAD and 13.2% of DAT patients had depression of mild to moderate degrees. Analysis revealed that diagnosis of VAD and DAT, heart disease, and past history of depression was significantly associated with high depression scores. There was no correlation between degree of depression and severity of cognitive impairments. Concludes that mild to moderate depression is a common comorbidity with organic dementia, especially VAD, but associated depression is independent of severity of cognitive impairments.
Longitudinal follow-up of depressive symptoms among normal versus cognitively impaired elderly
- Authors:
- LI Yan-Sheng, MEYER John S., THORNBY John
- Journal article citation:
- International Journal of Geriatric Psychiatry, 16(7), July 2001, pp.718-727.
- Publisher:
- Wiley
This prospectively designed longitudinal study assesses prevalence, incidence and prognosis of depressive symptoms among cognitively normal elderly volunteers compared with patients with mild cognitive impairment (MCI), dementia of Alzheimer type (DAT), and vascular dementia (VAD). Possible relationships between depressive symptoms, cognitive performance, disease types, and effects of antidepressant treatment were analysed. Concludes that depressive symptoms among DAT patients have higher rates of spontaneous resolution, without requiring intensive drug treatment, than among VAD patients in whom depressive symptoms are more persistent and refractory to drug treatment. Early depressive symptoms among subjects with MCI may represent a preclinical sign and should be considered as a risk factor for impending DAT or VAD among the elderly.