Search results for ‘Subject term:"alzheimers disease"’ Sort:
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American Journal of Alzheimer's Disease and other Dementias
- Publisher:
- Sage
American Journal of Alzheimer's Disease and other Dementias is an international, open access, peer reviewed journal that focuses on all aspects of Alzheimer's disease. AJADD publishes original research, case studies and media reviews on all aspects of Alzheimer's and dementia. Coverage on Social Care Online from this journal is limited to relevant systematic reviews and service evaluations only. (Edited publisher abstract)
Alzheimer’s and Dementia
- Publisher:
- Elsevier
This is the journal of the Alzheimer's Association in the United States. It publishes the results of studies in: behaviour, biochemistry, genetics, molecular biology, pharmacology, physiology, protein chemistry, neurology, neuropathology, psychiatry, geriatrics, neuropsychology, epidemiology, sociology, health services research, health economics, political science and public policy. Content emphasizes interdisciplinary investigations, integrative/translational articles, related to: etiology, risk factors, early detection, disease modifying interventions, prevention of dementia and applications of new technologies in health services. Coverage on Social Care Online from this journal is limited to relevant systematic reviews only.
Awareness in severe Alzheimer’s disease: a systematic review
- Authors:
- O'SHAUGHNESSY N. J., et al
- Journal article citation:
- Aging and Mental Health, 25(4), 2021, pp.602-612.
- Publisher:
- Taylor and Francis
Objective: There is limited understanding about how people in the severe stages of Alzheimer’s disease (AD) experience and demonstrate awareness. We synthesised all available evidence with the aim of understanding how awareness is preserved or impaired in severe AD and what evidence there is for different levels of awareness according to the levels of awareness framework. Method: A systematic search of the following databases: Embase, PsycINFO, MEDLINE and Web of Science was carried out. A narrative synthesis and analysis was conducted of all included studies. All studies were assessed for quality using the AXIS and CASP tools. Results: Our findings suggest that lower level sensory awareness is relatively maintained in severe AD. Findings for higher level awareness are variable and this may be related to the diversity of methods that have been used to explore awareness in these circumstances. Conclusion: Awareness is complex, heterogeneous and varies significantly between individuals. Environmental and contextual factors have a significant impact on whether awareness is observed in people with severe AD. Adaptation of the environment has the potential to facilitate the expression of awareness while education of caregivers may increase understanding of people with severe AD and potentially improve the quality of care that is received. (Edited publisher abstract)
End-of-life care among nursing home residents with dementia varies by nursing home and market characteristics
- Authors:
- ORTH Jessica, et al
- Journal article citation:
- Journal of the American Medical Directors Association, 22(2), 2021, pp.320-328.
- Publisher:
- Elsevier (for the American Medical Directors Association)
Objectives: Nursing homes (NHs) are critical end-of-life (EOL) care settings for 70% of Americans dying with Alzheimer's disease/related dementias (ADRD). Whether EOL care/outcomes vary by NH/market characteristics for this population is unknown but essential information for improving NH EOL care/outcomes. Our objectives were to examine variations in EOL care/outcomes among decedents with ADRD and identify associations with NH/market characteristics. Design: Cross-sectional. Outcomes: Place-of-death (hospital/NH), presence of pressure ulcers, potentially avoidable hospitalizations (PAHs), and hospice use at EOL. Key covariates were ownership, staffing, presence of Alzheimer's units, and market competition. Setting and Participants: Long-stay NH residents with ADRD, age 65 + years of age, who died in 2017 (N = 191,435; 14,618 NHs) in NHs or hospitals shortly after NH discharge. Methods: National Medicare claims, Minimum Data Set, public datasets. Descriptive analyses and multivariable logistic regressions. Results: As ADRD severity increased, adjusted rates of in-hospital deaths and PAHs decreased (17.0% to 6.3%; 11.2% to 7.0%); adjusted rates of dying with pressure ulcers and hospice use increased (8.2% to 13.5%; 24.5% to 40.7%). Decedents with moderate and severe ADRD had 16% and 13% higher likelihoods of in-hospital deaths in for-profit NHs. In NHs with Alzheimer's units, likelihoods of in-hospital deaths, dying with pressure ulcers, and PAHs were significantly lower. As ADRD severity increased, higher licensed nurse staffing was associated with 14%‒27% lower likelihoods of PAHs. Increased NH market competition was associated with higher likelihood of hospice use, and lower likelihood of in-hospital deaths among decedents with moderate ADRD. Conclusions and Implications: Decedents with ADRD in NHs that were nonprofit, had Alzheimer's units, higher licensed nurse staffing, and in more competitive markets, had better EOL care/outcomes. Modifications to state Medicaid NH payments may promote better EOL care/outcomes for this population. Future research to understand NH care practices associated with presence of Alzheimer's units is warranted to identify mechanisms possibly promoting higher-quality EOL care. (Edited publisher abstract)
A Structured Cognitive Intervention Pathway as a decision-support tool for non-pharmacological interventions within a dementia care service (innovative practice)
- Authors:
- CARTER Mark, et al
- Journal article citation:
- Dementia: the International Journal of Social Research and Practice, 20(1), 2021, pp.398-409.
- Publisher:
- Sage
Individual cognitive interventions for Alzheimer’s disease have been shown to be beneficial and cost effective when evaluated as sole interventions. However, there is a need for a systematic, person-centric, structured approach to guide non-pharmacological intervention selection based on disease stage, symptoms, outcome assessment, and individual requirements. Our Structured Cognitive Intervention Pathway aims to facilitate the selection of first-line, or subsequent, non-pharmacological management for people with Alzheimer’s disease living at home and in elderly care facilities. We discuss the Pathway’s conceptual basis and evaluation of implementation as a decision-support tool within a dementia care service in China. (Edited publisher abstract)
Journal of Alzheimer’s Disease
- Publisher:
- IOS Press
- Place of publication:
- Amsterdam
The Journal of Alzheimer’s Disease is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer’s disease. Relevant systematic reviews from this journal are indexed and abstracted selectively on Social Care Online. (Edited publisher abstract)
Caregiver burden in family carers of people with dementia with Lewy bodies and Alzheimer's disease
- Authors:
- SVENDSBOE Ellen, et al
- Journal article citation:
- International Journal of Geriatric Psychiatry, 31(9), 2016, pp.1075-1083.
- Publisher:
- Wiley
Objective: To characterise the differences in caregiver distress between carers of people diagnosed with dementia with Lewy bodies (DLB) and people with Alzheimer's disease (AD), with a view to differentiating and improving support for caregivers. Methods: This study is a part of two larger Norwegian studies, DemVest (n = 265) and The Norwegian Dementia Register (n = 2220), with data from caregivers and people diagnosed with AD (n = 100) and DLB (n = 86) between 2005 and 2013. The average age was 74.9 years (SD = 7.8). Caregiver distress was rated by the Relative Stress Scale. Diagnosis of the person receiving care was based on a comprehensive standardised assessment program (International Classification of Diseases, Revision 10 or Diagnostic and Statistical Manual for Mental Disorders, fourth edition). Additional data collected from people receiving care were neuropsychiatric symptoms, comorbidity and activities of daily living (ADL) score. Linear regression analyses were applied, first unadjusted and then in stepwise-adjusts in addition to descriptive analyses. Results: Caregivers to people with AD (20.2%) and 40% of caregivers for people with DLB experienced moderate or high caregiver burden with an increased risk of psychiatric disorders in the early stage of dementia. High Relative Stress Scale (RSS) total scores in caregivers was significantly associated with neuropsychiatric symptoms and also with impaired ADL functioning. Conclusion: Caregiver distress differed between people caring for someone with AD (15.0) and those caring for someone with DLB (19.9). These findings have direct implications for the needs and resources that could be available for these individuals and indicate the need for further research into caregiver burden in carers to people with DLB. (Edited publisher abstract)
New approaches to understanding dementia
- Author:
- GINESI Laura
- Journal article citation:
- Nursing Times, 112(25), 2016, pp.16-19.
- Publisher:
- Nursing Times
Improving understanding of brain disorders is likely to be one of the core aims of physiological research in the 21st century. This article, the second in a four-part series, looks at the main types of dementia and explores emerging theories about how the condition develops. These theories are improving understanding of the neuro-degeneration that characterises the most common forms of dementia, and will help improve care for those living with dementia. (Publisher abstract)
Moderate-to-high intensity aerobic exercise in patients with mild to moderate Alzheimer's disease: a pilot study
- Authors:
- FREDERIKSEN Kristian S., et al
- Journal article citation:
- International Journal of Geriatric Psychiatry, 29(12), 2014, pp.1242-1248.
- Publisher:
- Wiley
Objectives: Physical exercise may modulate neuropathology and symptoms of Alzheimer's disease (AD). This pilot study assessed the feasibility of conducting a study of moderate-to-high intensity aerobic exercise in home-dwelling patients with mild AD. Methods: An uncontrolled pre-intervention - post-intervention test design with a single group receiving the same intervention. A total of eight patients with mild to moderate AD from the Copenhagen Memory clinic were included in the study. The intervention lasted for 14 weeks and consisted of supervised, 1-h sessions of aerobic exercise three times per week (50-60% of heart rate reserve for a two-week adaptation period and 70-80 % of heart rate reserve for the remaining 12 weeks) Feasibility was assessed based on acceptability, including attendance and drop-out, safety, and patients' and caregivers' attitudes towards the intervention as well as other relevant parameters. Results: Attendance (mean, range: 90 %, 70-100 %) and retention (seven out of eight) rates were very high. No serious adverse events were observed. In general, patients and caregivers were positive towards the intervention. Conclusion: This study shows that it is feasible to conduct moderate-to-high intensity aerobic exercise in community-dwelling patients with mild AD. The findings indicate that aspects such as a longer adaptation period, information about injury prevention, and need for involvement and support from caregivers should be addressed when planning an exercise intervention in an AD population. (Edited publisher abstract)