Does a history of alcohol use disorder affect response to antidepressant medication in patients with dysthymic disorder?

ARNAOUT Bachaar, et al
Journal article citation:
Journal of Dual Diagnosis, 4(4), 2008, pp.377-393.
Taylor and Francis
Place of publication:
Philadelphia, USA

This study is based on secondary analysis of clinical trial data and covers 123 participants with dysthymic disorder (a type of depression). Of these, 99 had no history of alcohol use disorder while 24 did although no participant met the criteria for this disorder in the six months prior to the study. After eight weeks of antidepressant treatment, the two groups did not differ in rates of response or remission despite significantly higher baseline depression scores in the alcohol use disorder group. This group also experienced a greater reduction in symptoms. Dysthymic disorder is therefore judged to be as responsive to drug treatment among remitted alcoholics as among non-alcoholics. Further research to confirm the results is warranted. (Copies of this article are available from: Haworth Document Delivery Centre, Haworth Press Inc., 10 Alice Street,  Binghamton, NY 13904-1580).

Subject terms:
medication, outcomes, alcohol misuse, depression, dual diagnosis;
Content type:
United States
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